Smith joins Frances H. Arnold, a professor of chemical engineering at the California Institute of Technology, and Gregory P. Winter, a biochemist at the M.R.C. Laboratory of Molecular Biology in England, as the three 2018 winners.
Smith is the first University of Missouri professor to receive a Nobel Prize for research conducted at the university. He developed phage display, which allows a virus that infects bacteria to evolve new proteins. He was particularly focused on applying phage display to develop vaccines for malaria and other difficult diseases.
“This is truly an amazing day for Professor Smith, the University of Missouri and the state of Missouri,” MU Chancellor Alexander N. Cartwright said. “The Nobel Prize represents Dr. Smith’s significant contribution to chemistry and biology, as well as to the university over his 40-year career.”
Today, scientists are creating innovative applications for phage display, including developing antibody therapeutics and discovering stress fractures in steel. Phage display research can lead to the discovery of antibodies that neutralize toxins, combat metastasized cancers, and fend off autoimmune diseases. Phage display is used in laboratories worldwide as the basis for a wide range of experiments. An antibody drug that’s based on Smith’s research and was approved in 2002 is currently being used to treat rheumatoid arthritis, psoriasis and inflammatory bowel disease.
Smith joined the faculty of the MU College of Arts and Science in the Division of Biological Sciences in 1975. The University of Missouri Board of Curators appointed him a Curators Distinguished Professor in 2000, and he became a professor emeritus in 2015. He has authored and coauthored more than 50 articles in top scientific journals, and he was selected by the American Society of Microbiology for its 2007 Promega Biotechnology Research Award.