Seven people have been transported to a local hospital.
The crash occurred around noon, and MoDOT estimated the area would remain closed at least until 1 p.m. Multiple police and emergency vehicles were on the scene.
As of 1:15 p.m., MoDOT reported that one west lane was open at mile marker 214, but traffic was backed up for 5 miles in the westbound lanes and slow for 1 mile in the eastbound lanes.
Fox 2 News is on the scene and posting updates on their site.